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Emde degradation : ウィキペディア英語版 | Emde degradation The Emde degradation (also called Emde-reaction or Emde-reduction) is a method for the reduction of a quaternary ammonium cation to a tertiary amine with sodium amalgam 〔 H. Emde. ''Ber deutsch chem Ges'' 42 (1909) p2590〕〔 W Pötsch. ''Lexikon bedeutender Chemiker'' (VEB Bibliographisches Institut Leipzig, 1989) (ISBN 3817110553 〕〔 M B Smith, J March. ''March's Advanced Organic Chemistry'' (Wiley, 2001) (ISBN 0-471-58589-0)〕 This organic reaction was first described in 1909 by the German chemist Hermann Emde and was for a long time of great importance in structure elucidation of many alkaloids, for example that of ephedrine. Alternative reducing agents exist for this reaction; for instance, lithium aluminium hydride. ==See also ==
* Related reactions are the Hofmann elimination and the Von Braun reaction
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